IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer.
Identifieur interne : 000C21 ( Main/Exploration ); précédent : 000C20; suivant : 000C22IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer.
Auteurs : Hassan Yousefi [Iran] ; Majid Momeny [Iran] ; Seyed H. Ghaffari [Iran] ; Nazanin Parsanejad [Iran] ; Arash Poursheikhani [Iran] ; Sepehr Javadikooshesh [Iran] ; Ghazaleh Zarrinrad [Iran] ; Fatemeh Esmaeili [Iran] ; Zivar Alishahi [Iran] ; Zahra Sabourinejad [Iran] ; Ghazaleh Sankanian [Iran] ; Sahar Shamsaiegahkani [Iran] ; Davood Bashash [Iran] ; Narjes Shahsavani [Canada] ; Javad Tavakkoly-Bazzaz [Iran] ; Kamran Alimoghaddam [Iran] ; Ardeshir Ghavamzadeh [Iran]Source :
- Tumori [ 2038-2529 ] ; 2019.
Descripteurs français
- KwdFr :
- Anticorps monoclonaux humanisés (pharmacologie), Carboplatine (pharmacologie), Facteur de transcription NF-kappa B (métabolisme), Femelle, Humains, Interleukine-6 (métabolisme), Lignée cellulaire tumorale, Récepteurs à l'interleukine-6 (métabolisme), Résistance aux médicaments antinéoplasiques (), Transduction du signal (), Tumeurs de l'ovaire (métabolisme), Tumeurs de l'ovaire (traitement médicamenteux).
- MESH :
- métabolisme : Facteur de transcription NF-kappa B, Interleukine-6, Récepteurs à l'interleukine-6, Tumeurs de l'ovaire.
- pharmacologie : Anticorps monoclonaux humanisés, Carboplatine.
- traitement médicamenteux : Tumeurs de l'ovaire.
- Femelle, Humains, Lignée cellulaire tumorale, Résistance aux médicaments antinéoplasiques, Transduction du signal.
English descriptors
- KwdEn :
- Antibodies, Monoclonal, Humanized (pharmacology), Carboplatin (pharmacology), Cell Line, Tumor, Drug Resistance, Neoplasm (drug effects), Female, Humans, Interleukin-6 (metabolism), NF-kappa B (metabolism), Ovarian Neoplasms (drug therapy), Ovarian Neoplasms (metabolism), Receptors, Interleukin-6 (metabolism), Signal Transduction (drug effects).
- MESH :
- chemical , metabolism : Interleukin-6, NF-kappa B, Receptors, Interleukin-6.
- chemical , pharmacology : Antibodies, Monoclonal, Humanized, Carboplatin.
- drug effects : Drug Resistance, Neoplasm, Signal Transduction.
- drug therapy : Ovarian Neoplasms.
- metabolism : Ovarian Neoplasms.
- Cell Line, Tumor, Female, Humans.
Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, the majority of patients have chemoresistant disease. There is no treatment strategy with proven efficacy against chemoresistant EOC and in this setting, overcoming therapy resistance is the key to successful treatment.
DOI: 10.1177/0300891618784790
PubMed: 30021477
Affiliations:
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Le document en format XML
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Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Alishahi, Zivar" sort="Alishahi, Zivar" uniqKey="Alishahi Z" first="Zivar" last="Alishahi">Zivar Alishahi</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran 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sortKey="Alimoghaddam, Kamran" sort="Alimoghaddam, Kamran" uniqKey="Alimoghaddam K" first="Kamran" last="Alimoghaddam">Kamran Alimoghaddam</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Ghavamzadeh, Ardeshir" sort="Ghavamzadeh, Ardeshir" uniqKey="Ghavamzadeh A" first="Ardeshir" last="Ghavamzadeh">Ardeshir Ghavamzadeh</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30021477</idno><idno type="pmid">30021477</idno><idno type="doi">10.1177/0300891618784790</idno><idno type="wicri:Area/PubMed/Corpus">000707</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000707</idno><idno type="wicri:Area/PubMed/Curation">000707</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000707</idno><idno type="wicri:Area/PubMed/Checkpoint">000454</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000454</idno><idno 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sort="Poursheikhani, Arash" uniqKey="Poursheikhani A" first="Arash" last="Poursheikhani">Arash Poursheikhani</name><affiliation wicri:level="1"><nlm:affiliation>4 Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>4 Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad</wicri:regionArea><wicri:noRegion>Mashhad</wicri:noRegion></affiliation></author><author><name sortKey="Javadikooshesh, Sepehr" sort="Javadikooshesh, Sepehr" uniqKey="Javadikooshesh S" first="Sepehr" last="Javadikooshesh">Sepehr Javadikooshesh</name><affiliation wicri:level="1"><nlm:affiliation>5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>5 Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences</wicri:regionArea><wicri:noRegion>Shahid Beheshti University of Medical Sciences</wicri:noRegion></affiliation></author><author><name sortKey="Zarrinrad, Ghazaleh" sort="Zarrinrad, Ghazaleh" uniqKey="Zarrinrad G" first="Ghazaleh" last="Zarrinrad">Ghazaleh Zarrinrad</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Esmaeili, Fatemeh" sort="Esmaeili, Fatemeh" uniqKey="Esmaeili F" first="Fatemeh" last="Esmaeili">Fatemeh Esmaeili</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Alishahi, Zivar" sort="Alishahi, Zivar" uniqKey="Alishahi Z" first="Zivar" last="Alishahi">Zivar Alishahi</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Sabourinejad, Zahra" sort="Sabourinejad, Zahra" uniqKey="Sabourinejad Z" first="Zahra" last="Sabourinejad">Zahra Sabourinejad</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Sankanian, Ghazaleh" sort="Sankanian, Ghazaleh" uniqKey="Sankanian G" first="Ghazaleh" last="Sankanian">Ghazaleh Sankanian</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>2 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Shamsaiegahkani, Sahar" sort="Shamsaiegahkani, Sahar" uniqKey="Shamsaiegahkani S" first="Sahar" last="Shamsaiegahkani">Sahar Shamsaiegahkani</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Bashash, Davood" sort="Bashash, Davood" uniqKey="Bashash D" first="Davood" last="Bashash">Davood Bashash</name><affiliation wicri:level="1"><nlm:affiliation>6 Department of Hematology and Blood Banking, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>6 Department of Hematology and Blood Banking, Faculty of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Shahsavani, Narjes" sort="Shahsavani, Narjes" uniqKey="Shahsavani N" first="Narjes" last="Shahsavani">Narjes Shahsavani</name><affiliation wicri:level="4"><nlm:affiliation>7 Department of Physiology and Pathophysiology, Spinal Cord Research Center, University of Manitoba, Winnipeg, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>7 Department of Physiology and Pathophysiology, Spinal Cord Research Center, University of Manitoba, Winnipeg</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Tavakkoly Bazzaz, Javad" sort="Tavakkoly Bazzaz, Javad" uniqKey="Tavakkoly Bazzaz J" first="Javad" last="Tavakkoly-Bazzaz">Javad Tavakkoly-Bazzaz</name><affiliation wicri:level="1"><nlm:affiliation>2 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>2 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Alimoghaddam, Kamran" sort="Alimoghaddam, Kamran" uniqKey="Alimoghaddam K" first="Kamran" last="Alimoghaddam">Kamran Alimoghaddam</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Ghavamzadeh, Ardeshir" sort="Ghavamzadeh, Ardeshir" uniqKey="Ghavamzadeh A" first="Ardeshir" last="Ghavamzadeh">Ardeshir Ghavamzadeh</name><affiliation wicri:level="1"><nlm:affiliation>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>1 Hematology/Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tumori</title><idno type="eISSN">2038-2529</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal, Humanized (pharmacology)</term><term>Carboplatin (pharmacology)</term><term>Cell Line, Tumor</term><term>Drug Resistance, Neoplasm (drug effects)</term><term>Female</term><term>Humans</term><term>Interleukin-6 (metabolism)</term><term>NF-kappa B (metabolism)</term><term>Ovarian Neoplasms (drug therapy)</term><term>Ovarian Neoplasms (metabolism)</term><term>Receptors, Interleukin-6 (metabolism)</term><term>Signal Transduction (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux humanisés (pharmacologie)</term><term>Carboplatine (pharmacologie)</term><term>Facteur de transcription NF-kappa B (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Interleukine-6 (métabolisme)</term><term>Lignée cellulaire tumorale</term><term>Récepteurs à l'interleukine-6 (métabolisme)</term><term>Résistance aux médicaments antinéoplasiques ()</term><term>Transduction du signal ()</term><term>Tumeurs de l'ovaire (métabolisme)</term><term>Tumeurs de l'ovaire (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-6</term><term>NF-kappa B</term><term>Receptors, Interleukin-6</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Carboplatin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Drug Resistance, Neoplasm</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription NF-kappa B</term><term>Interleukine-6</term><term>Récepteurs à l'interleukine-6</term><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Carboplatine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Female</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Résistance aux médicaments antinéoplasiques</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy worldwide and despite an initial response to therapeutic agents, the majority of patients have chemoresistant disease. There is no treatment strategy with proven efficacy against chemoresistant EOC and in this setting, overcoming therapy resistance is the key to successful treatment.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Iran</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Iran"><noRegion><name sortKey="Yousefi, Hassan" sort="Yousefi, Hassan" uniqKey="Yousefi H" first="Hassan" last="Yousefi">Hassan Yousefi</name></noRegion><name sortKey="Alimoghaddam, Kamran" sort="Alimoghaddam, Kamran" uniqKey="Alimoghaddam K" first="Kamran" last="Alimoghaddam">Kamran Alimoghaddam</name><name sortKey="Alishahi, Zivar" sort="Alishahi, Zivar" uniqKey="Alishahi Z" first="Zivar" last="Alishahi">Zivar Alishahi</name><name sortKey="Bashash, Davood" sort="Bashash, Davood" uniqKey="Bashash D" first="Davood" last="Bashash">Davood Bashash</name><name sortKey="Esmaeili, Fatemeh" sort="Esmaeili, Fatemeh" uniqKey="Esmaeili F" first="Fatemeh" last="Esmaeili">Fatemeh Esmaeili</name><name sortKey="Ghaffari, Seyed H" sort="Ghaffari, Seyed H" uniqKey="Ghaffari S" first="Seyed H" last="Ghaffari">Seyed H. Ghaffari</name><name sortKey="Ghavamzadeh, Ardeshir" sort="Ghavamzadeh, Ardeshir" uniqKey="Ghavamzadeh A" first="Ardeshir" last="Ghavamzadeh">Ardeshir Ghavamzadeh</name><name sortKey="Javadikooshesh, Sepehr" sort="Javadikooshesh, Sepehr" uniqKey="Javadikooshesh S" first="Sepehr" last="Javadikooshesh">Sepehr Javadikooshesh</name><name sortKey="Momeny, Majid" sort="Momeny, Majid" uniqKey="Momeny M" first="Majid" last="Momeny">Majid Momeny</name><name sortKey="Parsanejad, Nazanin" sort="Parsanejad, Nazanin" uniqKey="Parsanejad N" first="Nazanin" last="Parsanejad">Nazanin Parsanejad</name><name sortKey="Poursheikhani, Arash" sort="Poursheikhani, Arash" uniqKey="Poursheikhani A" first="Arash" last="Poursheikhani">Arash Poursheikhani</name><name sortKey="Sabourinejad, Zahra" sort="Sabourinejad, Zahra" uniqKey="Sabourinejad Z" first="Zahra" last="Sabourinejad">Zahra Sabourinejad</name><name sortKey="Sankanian, Ghazaleh" sort="Sankanian, Ghazaleh" uniqKey="Sankanian G" first="Ghazaleh" last="Sankanian">Ghazaleh Sankanian</name><name sortKey="Shamsaiegahkani, Sahar" sort="Shamsaiegahkani, Sahar" uniqKey="Shamsaiegahkani S" first="Sahar" last="Shamsaiegahkani">Sahar Shamsaiegahkani</name><name sortKey="Tavakkoly Bazzaz, Javad" sort="Tavakkoly Bazzaz, Javad" uniqKey="Tavakkoly Bazzaz J" first="Javad" last="Tavakkoly-Bazzaz">Javad Tavakkoly-Bazzaz</name><name sortKey="Zarrinrad, Ghazaleh" sort="Zarrinrad, Ghazaleh" uniqKey="Zarrinrad G" first="Ghazaleh" last="Zarrinrad">Ghazaleh Zarrinrad</name></country><country name="Canada"><region name="Manitoba"><name sortKey="Shahsavani, Narjes" sort="Shahsavani, Narjes" uniqKey="Shahsavani N" first="Narjes" last="Shahsavani">Narjes Shahsavani</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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